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Jeremy M. Shaver, Ph.D.
Chief of Technology Development,
Eigenvector Research, Inc.
15835 10th Ave NE
Shoreline, WA 98155
phone: (206) 361-0023
fax: (206) 361-0023
e-mail: shaver@eigenvector.com
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Education:
Postdoctoral Research Fellow, University of Michigan, 1995-1997.
Ph.D. (Analytical Chemistry), Duke University, 1995.
B.A. (Chemistry), College of Wooster, 1991.
Experience:
June 2005 - present, Chief of Technology Development, Eigenvector
Research Inc., Manson, WA; Chemometric research, development, consultation
and software.
Feb 2001 - June 2005, Senior Scientist, Eigenvector Research Inc.,
Manson, WA; Chemometric research, development, consultation and
software.
July 1997 - Feb 2001, Applications Scientist, Kaiser Optical Systems
Inc., Ann Arbor, MI; Consultation and development for new imaging,
QC and on-line applications of Raman spectroscopy. Develop process
and QC analysis models, software and user interfaces.
September 1995 - July 1997, Postdoctoral Research Fellow, University
of Michigan, Ann Arbor, MI; Spectroscopic and chemometric research
with Professor Michael Morris including vibrational image analysis,
on-line detection of CE separations using Raman spectroscopy.
January 1996 - July 1997, Lecturer, University of Michigan, Ann
Arbor, MI.
September 1988 - August 1995, Research & Teaching Assistant,
Duke University (Durham, NC) and College of Wooster (Wooster, OH).
Research Interests:
Development and application of practical numerical analysis methods
for real-life systems from chemical production to disease detection
to multi-way and bio-informatics. Chemometric approaches which utilize
the unique advantages of the particular analytical measurement using
an understanding the analytical measurement and science of the system
under study. Characterizing the limitations of the chemometrics
for the particular application. Adapting powerful but simple-to-use
tools for non-chemometricians.
Professional Organizations and Activies:
Sigma Xi, Scientific Research Society; American Chemical Society
(Analytical Division); Society for Applied Spectroscopy; Phi Lambda
Upsilon (National Honorary Chemical Society); Cascade Flyers - Vice
President/Board Member (2003-present); Ann Arbor Flyers - Board
Member/Webmaster (2000-2002).
Honors:
Thomas Hirschfeld Graduate Student Award, FACSS (1995); Ethyl Corporation
(Lawrence E. Blanchard) Summer Fellowship (1994); Society for Applied
Spectroscopy, Piedmont Section, Graduate Student Award (1994); Lubrizol
Fellowship, Lubrizol Corporation Undergraduate Fellowship (1990).
Publications:
Lei, P., Jiang, G., Davis, R.C., Shaver J.M., Smentkowski, V.S.,
Asplund, M.C., Linford, M.R., "Laser Activation-Modification
of Semiconductor Surfaces (LAMSS) of 1-Alkenes on Silicon: A ToFSIMS,
Chemometrics, and AFM Analysis," submitted Appl. Surface Sci.
(8/2006).
Gallagher, N.B, Shaver, J.M., Windig, W., Blake, T.A., Gassman,
P.L. "Multivariate Curve Resolution Applied to Infrared Reflectance
Measurements of Soil Contaminated with Organic Analyte," Appl.
Spectrosc., 2006, 60(7), 713-722.
Gallagher, N.B., Shaver, J.M., Martin, E.B., Morris, J., Wise,
B.M. and Windig, W. "Curve resolution for images with applications
to TOF-SIMS and Raman," Chemo. and Intell. Lab. Sys., 2003,
77(1), 105-117.
Gallagher, N.B., Sheen, D.M., Shaver, J.M., Wise, B.M. and Schultz,
J.F. "Estimation of Trace Vapor Concentration-Pathlength in
Plumes for Remote Sensing Applications from Hyperspectral Images,"
SPIE Proceedings, 2003, 5093, 184-194.
Shaver, J.M. "Chemometrics for Raman Spectroscopy" in Handbook
of Raman Spectroscopy, Lewis and Edwards, editors, Marcel Dekker,
New York, 2001; pp 275-306.
Shaver, J. M., Christensen, K. A., Pezzuti, J. A., and Morris,
M. D., "Structure of Dihydrogen Phosphate Ion Aggregates by Raman-Monitored
Serial Dilution," Applied Spectroscopy, 1998, 52(2), 259-264.
Jestel, N. L., Shaver, J. M., and Morris, M. D., "Hyperspectral
Raman Line Imaging of an Aluminosilicate Glass," Applied Spectroscopy,
1998, 52 (1), 64-69.
Walker III, P. A., Shaver, J. M., and Morris, M. D., "Identification
of Cationic Herbicides in Deionized Water, Municipal Tap Water,
and River Water by Capillary Isotachophoresis / On-Line Raman Spectroscopy,"
Applied Spectroscopy, 1997, 51 (9), 1394-1399.
Shaver, J. M. and McGown, L. B., "Maximum Entropy Method Analysis
of Frequency-Domain Fluorescence Lifetime Data: 2. Timing, Mismatched
Intensity and Reference Lifetime Errors," Analytical Chemistry,
1996, 68(4), 611-620.
Shaver, J. M. and McGown, L. B., "Maximum Entropy Method Analysis
of Frequency-Domain Fluorescence Lifetime Data: 1. Effects of Frequency
Range and Random Noise," Analytical Chemistry, 1996, 68(1), 9-17.
Shaver, J. M. and McGown, L. B., "Fluorescence Characterization
of Complex Coal Liquid Samples using the Lifetime Synchronous Spectrum
(LiSS)," Applied Spectroscopy, 1995, 49(6), 813-818.
McGown, L. B., Hemmingsen, S. L. and Shaver, J. M., "Total Lifetime
Distribution Analysis for Fluorescence Fingerprinting and Characterization,"
Applied Spectroscopy, 1995, 49(1), 60-66.
Shaver, J. M. and McGown, L. B., "Generation of a New Spectral
Format, the Lifetime Synchronous Spectrum (LiSS), using Phase-Resolved
Fluorescence Spectroscopy," Applied Spectroscopy, 1994, 48(6), 755-760.
Smalley, M. B., Shaver, J. M. and McGown, L. B., "On-the-Fly Fluorescence
Lifetime Detection in HPLC Using a Multiharmonic Fourier Transform
Phase-Modulation Spectrofluorometer," Analytical Chemistry, 1993,
65, 3466-3472. (Selected for the 1993 Perkin-Elmer International
Liquid Chromatography Technical Paper Award)
Select Presentations:
Shaver, J. M., Lei, P., Jiang, G., Asplund, M.C., Linford, M.R.,"Robust
Multivariate Analysis for Problem Images," Federation of
Analytical Chemistry and Spectroscopy Societies, Lake Buena Vista,
FL, September 24-28, 2006.
Bryan, S. A., Levitskaia, T.G., Sinkov, S.I., Schlahta, S.N., Shaver,
J.M., "Raman based process monitor for continuous real-time
analysis of high level radioactive waste components," Meeting
of the American Chemical Society, San Francisco, CA, September 10-14,
2006.
Shaver, J. M., Wise, B. M., Koch, R. S., "Expanding
Chemometric Model Sophistication for Improved Performance in Industrial
Applications," Eastern Analytical Simposium, Somerset,
NJ, November 13-16, 2005.
Shaver, J. M., "Using
pre-whitening techniques for process model stabilization,"
Federation of Analytical Chemistry and Spectroscopy Societies, Quebec
City, Quebec, Canada, October 9-13, 2005.
Shaver, J. M., Gallagher, N.B., Wise, B.M., "Using
MATLAB and PLS_Toolbox for Online Process Monitoring,"
International Forum on Process Analytical Chemistry, Arlington,
VA, January 10-13, 2005.
Shaver, J. M., Wise, B.M. "Chemometric
Techniques for Two-way, Three-way and Higher-order Image Data,"
AVS 51st International Symposium, Anaheim, CA, November 14-19, 2004.
Wise, B. M. and Shaver, J. M. "Detection of Cervical Cancer
from Evoked Tissue Fluorescence Images using 2- and 3-Way Methods,"
Eastern Analytical Symposium, New Jersey, November, 14-19, 2004.
Shaver, J. M., Bryan, S.A, Levitskaia, T.G., and Sinkov, S.I. "Raman
Analysis of Concentrated Salt Solutions Using Robust Modeling and
Data Fusion," Federation of Analytical Chemistry and Spectroscopy
Societies, Portland, OR, October 3-7, 2004.
Wise, B. M. and Shaver, J. M. "Classification of Cervical
Tissue with Evoked Tissue Fluorescence Images using 2- and 3-Way
Methods," Chemometrics in Analytical Chemistry, Lisbon, Portugal,
September 20-23, 2004.
Shaver, J.M., Gallagher, N.B and Bro, R.B, "Local
Functional Constraints in Multivariate Curve Resolution,"
Federation of Analytical Chemistry and Spectroscopy Societies, Portland,
OR, October 19-23, 2003.
Shaver, J.M. "Finding
Specificity in Multivariate Curve Resolution," Federation
of Analytical Chemistry and Spectroscopy Societies, Portland, OR,
October 19-23, 2003.
Shaver, J.M., Gallagher, N.B. and Martin, E.B. "Multivariate
Curve Resolution of Hyperspectral Images: Initialization and Functional
Constraints," 8th Scandinavian Symposium on Chemometrics, Aland,
Finland, June 14-18, 2003.
Shaver, J. M., Gallagher, N.B., Wise, B.M., Martin, E.B. "Multivariate
Curve Resolution of Hyperspectral Images: Ambiguities and Low-Signal
Components," Spectrum-Imaging and Hyperspectral Data Analysis
Workshop - Microbeam Analysis Society, Gaithersburg, MD, April 28-May
1, 2003.
Gallagher, N.B., Shaver J.M., Martin, E.B., Thennadil, S.N. "Hyperspectral
Imaging for Process Monitoring and Process Analytical Chemistry"
International Forum on Process Analytical Chemistry, Phoenix, AZ,
January 21-24, 2003.
Shaver, J. M., Wright, S. "Automatic Declutter Approaches
using GLS with Discrete or Continuous Independent Variables,"
Chemometrics in Analytical Chemistry, Seattle WA, Sept. 22-26, 2002.
Shaver, J. M., Wise, B.M., Gallagher, N.B. "Thinking
Outside the POX - Alternatives for Stable Model Design,"
Annual Meeting of the Federation of Analytical Chemistry and Spectroscopy
Societies, Detroit, MI, October 8-12, 2001.
Shaver, J. M. "Correction Of Instrumental Artifacts In Raman
Spectroscopy And Its Effect On Chemometric Models," Annual
Meeting of the Federation of Analytical Chemistry and Spectroscopy
Societies, Detroit, MI, October 8-12, 2001.
Shaver, J. M. "Raman Calibration and Calibration Transfer
using Full-Ratio PCR and Piecewise Gaussian Blurring," Gordon
Research Conference on Statistics in Chemistry and Chemical Engineering,
Williams College, Williamstown, MA, July 22-27, 2001.
Shaver, J. M. "Spectral Analysis Techniques - Getting Process
Raman to WORK," International Forum on Process Analytical Chemistry,
Amelia Island, FL, January 21-24, 2001.
Shaver, J. M. "A Semi-Quantitative/Quantitative Platform for Reaction
Monitoring and On-Line Raman Analyses", Annual Meeting of the Center
for Process Analytical Chemistry, Seattle, WA, November 6, 2000.
Shaver, J. M. "Analytical Chemistry for Control of Chemical Reactors
in Industry", University of Michigan, Ann Arbor, MI, October 5,
2000.
Shaver, J. M. "Using the Raman Advantage in Real-Time Quantitative
Reaction Monitoring", Annual Meeting of the Federation of Analytical
Chemistry and Spectroscopy Societies, Nashville, TN, September 25-29,
2000.
Lewis, I. R., Shaver, J. M., Samford M.L. "Advances in Fiber-Coupled
Raman Microprobes and Chemical Mapping", International Union of
Microbeam Analysis Societies, Kona, HI, July 10-14, 2000.
Shaver, J. M. "Modeling and Instrumentation for Accurate On-Line
Raman Measurements", International Forum on Process Analytical Chemistry,
Las Vegas, NV, January 24-26, 2000.
Shaver, J. M. "Stabilizing Multi-Component Process Models-New Approaches
Using Relative Intensity", Federation of Analytical Chemistry and
Spectroscopy Societies, Vancouver, BC, October 25-29, 1999.
Shaver, J. M. "Simple and Robust Models for Process Raman Spectral
Analysis", The Pittsburgh Conference, Orlando, FL, March 7-12, 1999.
Shaver, J. M. and Pelletier, M. J. "Breaking Convention for Process-Suitable
Raman Models", Society for Applied Spectroscopy, Chicago section,
Naperville, IL, February, 17, 1999.
Shaver, J. M. "The Pursuit of Stable Process-Raman Models for an
Uncertain World", Invited talk, Anachem / Society for Applied Spectroscopy,
Detroit, MI, November, 1, 1998.
Shaver, J. M. "Analytical Laser Spectroscopy for Industrial Process
Monitoring and Quality Control", Invited talk, Ohio Weslean University,
Deleware, OH, October, 1, 1998.
Shaver, J. M. and Leugers, A. "On-Line Raman for Polyethylene Process
Monitoring and Control", Gulf Coast Conference, Galveston, TX, September,
15-17, 1998.
Shaver, J. M. and Pelletier, M. J. "Raman Analyzers for Polymer
Production and Processing", Workshop, Gulf Coast Conference, Galveston,
TX, September, 15-17, 1998.
Shaver, J. M. "Modern Process Raman Applications - From Benchtop
to Rooftop", Society for Applied Spectroscopy, Chicago section,
Naperville, IL, February, 25, 1998.
Shaver, J. M. "Raman Spectroscopy", Workshop, Eastern Analytical
Symposium, New Jersey, November, 1997.
Shaver, J. M., Jestel, N. L., and Morris, M. D., "Multivariate
Analysis of Hyperspectral Raman Data of Complex Samples," The Pittsburgh
Conference, Atlanta, GA, 3/16-21/1997.
Morris, M. D., Walker III, P .A., and Shaver, J. M., "Raman Spectroscopy/Capillary
Electrophoresis - Ultrasensitivty via On-line Preconcentration,"
The Pittsburgh Conference, Atlanta, GA, 3/16-21/1997.
Pezzuti, J. A., Shaver, J. M., and Morris, M. D., "Raman Microscopy
of Crystallizing Amino Acids and Carboxyllic Acids," The Pittsburgh
Conference, Atlanta, GA, 3/16-21/1997.
Jestel, N. L., Shaver, J. M., and Morris, M. D., "Raman Microspectroscopy
and Hyperspectral Raman Imaging of Silicate Glasses," The Pittsburgh
Conference, Atlanta, GA, 3/16-21/1997.
Shaver, J. M., Christensen, K. A. and Morris, M. D., "Multivariate
Techniques for Raman Image Enhancement," 23nd Annual Meeting of
the Federation of Analytical Chemistry and Spectroscopy Societies,
Kansas City, MO, 9/29-10/4/96.
Morris, M. D., Shaver, J. M., Christensen, K. A. and Bradley, N.
L., "Getting the Most Out of the Least: Data Transformation in Raman
Microspectroscopy and Imaging," 23nd Annual Meeting of the Federation
of Analytical Chemistry and Spectroscopy Societies, Kansas City,
MO, 9/29-10/4/96.
Christensen, K. A., Shaver, J. M. and Morris, M. D., "Micro-Raman
Studies of Crystalline Phosphates," 23nd Annual Meeting of the Federation
of Analytical Chemistry and Spectroscopy Societies, Kansas City,
MO, 9/29-10/4/96.
Shaver, J. M., Bonney, J. L. and Morris, M. D., "Modern Raman Spectroscopy
for Undergraduate Analytical Laboratories," 212th American Chemical
Society National Meeting, Orlando, FL, 8/25-29/96.
Shaver, J. M., Walker III, P. W. and Morris, M. D., "Statistically-Based
Correlation Analyses in Raman-Detected Capillary Electrophoretic
Separations," 15th International Conference On Raman Spectroscopy,
Pittsburgh, PA, 8/11-15/96.
Bradley, N. L., Shaver, J. M. and Morris, M. D., "Examination of
Glassy Materials by Raman Microspectroscopy and Imaging," 15th International
Conference On Raman Spectroscopy, Pittsburgh, PA, 8/11-15/96.
Walker III, P. W., Shaver, J. M. and Morris, M. D., "Detection
of Isotachophoretically Separated Quanternary Cationic Herbicides,"
15th International Conference On Raman Spectroscopy, Pittsburgh,
PA, 8/11-15/96.
Christensen, K. A., Shaver, J. M. and Morris, M. D., "A Raman Spectroscopic
and Imaging Study of Aqueous KDP and NaDP Freezing Phenomena in
a Buffer System," 15th International Conference On Raman Spectroscopy,
Pittsburgh, PA, 8/11-15/96.
Shaver, J. M., Lee, S. S. and McGown, L. B., "Elucidation of Molecular
Probe Distributions in Reverse Micelles by Total Lifetime Distribution
Analysis (TLDA)," Featured Presentation, 22nd Annual Meeting of
the Federation of Analytical Chemistry and Spectroscopy Societies,
Cincinnati, OH, 10/15-20/95.
Shaver, J. M., Hemmingsen, S. L., Joseph, M. J. and McGown, L.
B., "Rethinking Phase and Modulation Analysis: Novel Data Analysis
Techniques and Considerations for the New Generation of Frequency-Domain
Fluorescence Lifetime Instrumentation," The Pittsburgh Conference,
New Orleans, LA, 3/5-10/95.
Shaver, J. M. and McGown, L. B., "Complex Sample Analysis Using
Novel Phase-Resolved Fluorescence Spectroscopic Techniques," Invited
Speaker, The Society for Applied Spectroscopy Piedmont Section Annual
Meeting, Athens, GA, 3/31/1994.
Shaver, J. M. and McGown, L. B., "Characterization of Coal Liquid
Samples Using Novel Phase-Resolved Fluorescence Spectroscopic Techniques,"
The Pittsburgh Conference, Chicago, IL, 2/27-3/4/1994.
Shaver, J. M. and McGown, L. B., "Novel Spectral and Lifetime Resolved
Fluorescence Techniques," The Society of Photo-optical Instrumentation
Engineers' International Symposium on Biomedical Optics, Los Angles,
CA, 1/22-28/1994.
Shaver, J. M. and McGown, L. B., "Characterization of Residuum-Derived
Vacuum Gas Oil Samples Using Phase-Resolved Fluorescence Spectroscopy,"
The Pittsburgh Conference, Atlanta, GA, 3/7-12/1993.
Shaver, J. M. and McGown, L. B., "Improved Characterization of
Complex Coal Liquid Samples Using Phase-Resolved Fluorescence Spectroscopy,"
The 19th Annual Meeting of the Federation of Analytical Chemistry
and Spectroscopy Societies, Philadelphia, PA, 9/20-25/1992.
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