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Education: Ph.D., Analytical Chemistry, December 1989, University of Washington; B.A. Magna Cum Laude, Chemistry, June 1985, Oberlin College; State University of New York at Binghamton, September 1981 to December 1982. Experience: Summary: 19 years of experience in chemometrics, near-infrared (NIR) spectroscopy, and process analytical chemistry, including 12 years of experience in applying these technologies to industrial problems in both R&D and manufacturing. April 2005 - present: Senior Scientist, Eigenvector Research Inc., Manson WA; Chemometrics consulting and training; Chemometrics research, and software development. June 1996 - April 2005: Consultant, DuPont Engineering Technologies- Measurement Systems Technology, located at the Houston TX Regional Engineering Office; design, installation and support of process analyzer systems, maintenance training, hardware and software support, development and maintenance of analytical methods- for manufacturing plants, pilot plants, and research operations; supported a wide array of DuPont internal businesses as well as DuPont Central Research; company-wide resource in process spectroscopy and chemometrics. February 2001 - present: Consultant, DuPont Senplex Chemical Sensors- Use of chemometrics to support both development and calibration of new chemical sensing array devices. October 1992 - June 1996: Research Chemist, DuPont Central Research and Development- Polymer Property Measurement Group, located at Sabine River Works, Orange TX, development and support of on-line spectroscopy, rheology and gas chromatography measurements and chemometric calibrations, primarily for DuPont's Packaging and Industrial Polymers business. May 1991 - October 1992: Postdoctoral Researcher, Norwegian Food Research Institute, Ås, Norway: NIR and chemometrics applied to the analysis of foods and food packaging materials. April 1990 - April 1991: Postdoctoral Researcher, Max Planck Institute for Polymer Research, Mainz, Germany: Fundamental studies of Al2O3 surface interactions by surface plasmon resonance (SPR) and other surface analytical methods. December 1989 - March 1990: Postdoctoral Researcher, Laboratory for Chemometrics, University of Washington, Seattle WA; development of IR emission spectroscopy as an on-line sensing method. July 1989: Research Intern, ICI Polyurethanes, West Deptford NJ; non-destructuve analysis of reaction-injection-molded polyurethanes by NIR spectroscopy and chemometrics. June 1988 - September 1988: Research Intern, The Goodyear Tire and Rubber Company, Akron OH: analysis of rubber, bulk polyester, and polyester fiber by NIR and chemometrics. June 1985 - September 1985: Research Intern, Procter and Gamble Company, Cincinnati OH: application of NIR and chemometrics for the analysis of consumer product raw materials. September 1984 - June 1985: Research Assistant, Oberlin College, Oberlin OH; Use of Enzymatically Active Reactors for Flow Injection Analysis. June 1984 - September 1984: Research Assistant, Oberlin College,
Oberlin OH; Organic Synthesis and Low temperature IR and Raman Spectroscopy. Employment Objective : Develop, implement and support process analytical and chemometrics technologies. Research Interests: Development of improved chemometric modeling and data pre-processing techniques, primarily applied to data obtained from on-line and laboratory analytical techniques; Development of techniques to apply prior knowwledge of chemistry, analytical methods and process dynamics to improve the robustness of such applications; Multivariate sensor array technologies; "Optical Chemometrics" techologies; On-line spectroscopy (primarily Near-Infrared) technologies; Data mining and exploratory analysis techniques to extract valuable information from existing databases. Development of software tools to enable efficient support and maintenance of a large number of calibration models. Professional Organizations and Activities: Editorial board for the Journal of Chemometrics; International Chemometrics Society; American Chemical Society; Society for Applied Spectroscopy (SAS); jury chairman for the Eastern Analytical Symposium (EAS) Chemometrics Award; reviewer for the Jourrnal of Chemometrics, Applied Spectroscopy, Analytical Chemistry, Chemometrics and Intelligent Laboratory Systems, J. Appl. Poly. Sci., Macromolecules, J. Near Infrared Spectrosc., and Talanta; Leader of "Chemometrics for On-Line Process Analyzers" (COPA) initiative (sponsored by CPAC); Taught the course "Chemometrics in Analytical Chemistry and Spectroscopy for the SAS since 1997; Phi Beta Kappa (since 1984), Sigma Xi (since 1985). Honors: Tomas Hirschfeld Award in Near infrared Analysis (1990); Post-doctoral fellowship: Max-Planck-Institute for Polymer Research (1990); Post-doctoral fellowship: Norwegian Council for Scientific and Industrial Research (1991 and 1992); Honors Undergraduate Research Program, Oberlin College (1985); New York State Regents Scholarship (1981); Poster Awards: Bayreuth Polymer and Material Research Symposium (Bayreuth, Germany, 1991), 5th Intl. Conf. on Near-infrared Spectroscopy (Haugesund, Norway, 1992); Volunteer Recognition Award- DuPont (2004, math tutoring). Publications: C.E. Miller, ”Chemometrics in Process Analytical Chemistry”, in Process Analytical Chemistry, Blackwell Publishing, Oxford, 2004, in press. C.E. Miller, ”Near Infrared Spectroscopy of Synthetic and Industrial Samples”, in The Handbook of Vibrational Spectroscopy, Volume I: Theory and Instrumentation, John Wiley and Sons, Chichester, U.K., 2002, pp. 196-211. C.E. Miller, ”Chemometrics for On-Line Spectroscopy Applications- Theory and Practice”, J. Chemometrics, 14, pp. 513-528 (2000). C.E. Miller, ”Chemometric Tools and NIR Spectroscopy- A Match Made in Heaven?”, American Pharmaceutical Review, May 1999, pp. 41-48. C.E. Miller, “Analytical Chemistry ‘On The Line’ (An Academic Chemist Gets a ‘Real Job’ in Process Analysis), Spectroscopy, 12(1), Jan. 1997, p. 24. C.E. Miller, “Analytical Chemistry ‘On The Line’”, ACS Division Anal. Chem., Fall 1996 Newsletter. C.E. Miller, "Chemical Principles of Near-Infrared Technology", in Near Infared Spectroscopy in the Agricultural and Food Industries, 2nd edition, Phil Williams and Karl Norris, editors, American Association of Cereal Chemists, St. Paul MN, 2001, pp. 19-37. C.E. Miller, "The Use of Chemometric Techniques in Process Analytical Method Development and Operation", Chemomstrics Intell. Lab Syst., 30(1), pp. 11-22 (1995). C.E. Miller, "Sources of Non-Linearity in Near-Infrared Methods", NIR News, 4(6), 3 (1993). C.E. Miller, "Rapid and Non-Destructive Quality Assessment of Polymeric Films Using Near-Infrared Spectroscopy", Proc. SPE Polyolefins VIII International Conference (Feb. 21-24, 1993, Houston TX), p. 616. C.E. Miller, "Use of Near-Infrared Spectroscopy to Determine the Composition of High-Density/Low-Density Polyethylene Blend Films", Appl. Spectrosc., 47(2), 222 (1993). C.E. Miller, S.A. Svendsen, T. Næs, "Non-destructive Characterizations of Polyethylene/Nylon Laminates by Near-infrared Spectroscopy", Appl. Spectrosc., 47(3), 346 (1993). C.E. Miller, "NIR-More than a Non-invasive Composition Sensor: Applications to Polymeric Food Packaging", Proc. 5th Intl. Conf. on Near-infrared Spectroscopy (Haugesund, NORWAY, June 1992), Ellis-Horwood: New York, 1992, p. 413. T. Næs, K. Kvaal, T. Isaksson, C. Miller, "Artificial Neural Networks in Multivariate Calibration", J. Near Infrared Spectrosc., 1, 1-11 (1993). C.E. Miller, "NIR-FT-Raman Spectroscopy and PLS-2 Modeling for Improved Understanding of Near-infrared Spectra", Spectrochimica Acta, 49A(5/6), 621 (1993). T. Isaksson, C.E. Miller, T. Næs, "Non-destructive NIR and NIT Determination of Protein, Fat and Water in Plastic-wrapped, Homogenized Meat", Appl. Spectrosc., 46(11), 1685 (1992). C.E. Miller, W.H. Meyer, W. Knoll, G. Wegner, "Surface Plasmon Resonance as a Technique to Study Adsorption to Aluminum Oxide Surfaces", Berichte der Bunsengesellschaft für Physikalische Chemie, 96(7), 871 (1992). C.E. Miller, N.M. Reynolds, "The Use of Principal Components Analysis for Detailed Observation of the Effects of Deformation and Relaxation on the C=O Stretching Band of a Block Polyurethane", SPIE Proceedings Vol. 1575 (8th Intl. Conf. on Fourier Transform Spec., Lübeck, GERMANY, Sept. 1991), 521. C.E. Miller, "Non-destructive NIR Analyses of Bulk Polymeric Systems", Proc. 4th Intl. Conf. on Near-infrared Spectroscopy (Aberdeen, SCOTLAND, Aug. 1991). C.E. Miller, "Near-infrared Spectroscopy of Synthetic Polymers", NIR News, 2, 8 (1991). C.E. Miller, "Near-Infrared Spectroscopy of Synthetic Polymers", Appl. Spectrosc. Rev., 26(4), 275 (1991). C.E. Miller, B.E. Eichinger, "Analysis of RIM Polyurethanes by Near-infrared Diffuse Reflectance Spectroscopy", J. Appl. Poly. Sci., 42(8), 2169 (1991). B.D. Rasco, C.E. Miller, T.L. King, "Utilization of NIR Spectroscopy to Estimate the Proximate Composition of Trout Muscle with Minimal Sample Pretreatment", J Agr. Food Chem., 39, 67 (1991). R.J. Pell, C.E. Miller, B.R. Kowalski, J.B. Callis, C.E. Miller, "Infrared Emission Spectroscopy with Transient Cooling", Appl. Spectrosc., 47(12), 2064 (1993). C.E. Miller, D.D. Archibald, M.L. Myrick, S.M. Angel, "Determination of Physical Properties of RIM Polyurethanes by Near-infrared FT-Raman Spectroscopy", Appl. Spectrosc., 44(8), 1297 (1990). C.E. Miller, T. Næs, "A Path-length Correction Method for Near-infrared Spectroscopy", Appl. Spectrosc., 44(5), 895 (1990). C.E. Miller, B.E. Eichinger, "Analysis of Rigid Polyurethane Foams by Near-infrared Diffuse Reflectance Spectroscopy", Appl. Spectrosc., 44(5), 887 (1990). C.E. Miller, P.G. Edelman, B.D. Ratner, B.E. Eichinger, "Near-infrared Spectroscopic Analysis of Polyether(urethaneurea) Block Copolymers, II. Phase Separation", Appl. Spectrosc., 44(4), 581 (1990). C.E. Miller, P.G. Edelman, B.D. Ratner, "Near-infrared Spectroscopic Analysis of Polyether(urethaneurea) Block Copolymers, I. Bulk Composition", Appl. Spectrosc., 44(4), 576 (1990). C.E. Miller, B.E. Eichinger, "Determination of Crystallinity and Morphology of Fibrous and Bulk Poly(ethylene terephthalate) by Near-infrared Diffuse Reflectance Spectroscopy", Appl. Spectrosc., 44(3), 496 (1990). C.E. Miller, B.E. Eichinger, T.W. Gurley, J.G. Hermiller, "Determination of Microstructure and Composition of Butadiene and Styrene-Butadiene Polymers by Near-infrared Spectroscopy", Anal. Chem., 62, 1778 (1990). C.E. Miller, "Analysis of EPDM Terpolymers by Near-infrared Spectroscopy and Multivariate Calibration Methods", Appl. Spectrosc., 43(8), 1435 (1989). C.E. Miller, D.E. Honigs, "Discrimination of Different Crystalline Phases Using Near-infrared Diffuse Reflectance Spectroscopy", Spectroscopy, 4, 44 (1989). C.E. Miller, T-K. Yin, "Near-infrared Reflectance Analysis of Poly[octadecyl methacrylate] Adsorbed on Alumina", J. Mat Sci. Lett., 8, 467 (1989). D.D. Archibald, C.E. Miller, L.T. Lin, D.E. Honigs, "Remote Near-IR Reflectance Measurements with the use of a Pair of Optical Fibers and a Fourier Transform Spectrometer", Appl. Spectrosc., 42(8), 1549 (1988). A.M.C. Davies, C.E. Miller, "Tentative Assignment of the 1440 nm Band in the Near-infrared Spectrum of Crystalline Sucrose", Appl. Spectrosc., 42(4), 703 (1988). C.E. Miller, D.E. Honigs, "Determination of Polycyclic Aromatic Hydrocarbons in Fuels: Recent Analyses and New Developments", Spectroscopy, 2(8), 30 (1987). R.Q. Thompson, H. Kim, C.E. Miller, "Experimental Comparison of Immobilized Enzyme Reactors for Flow-injection Systems", Anal. Chim. Acta, 198, 165 (1987). Selected Presentations (* = invited): *C.E. Miller, "Diverse Solutions for Process Analyzer Reliability", 18th International Forum Process Analytical Chemistry (IFPAC), Arlington VA, January 2004. *C.E. Miller, "Chemometrics in Process Analytical Method Development and Operation", Process Analytical Technologies- Complying with Evolving Risk-Based Part 11 and GMP Guidelines, Philadelphia PA, September 2003. *C.E. Miller, "The Balance Between Accuracy and Relevance in Process Spectroscopy Method Development", 17th International Forum Process Analytical Chemistry (IFPAC), Phoenix, AR, January 2003. *C.E. Miller, "Multivariate Curve Resolution to Support Business Renewal", 29th Annual FACSS Conference, Providence RI, October 2002. *C.E. Miller, "On-Line Chemometrics- An Industrial Perspective", 16th International Forum Process Analytical Chemistry (IFPAC), San Diego CA, January 2002. C.E. Miller, "The Use of Constrained Multivariate Curve Resolution to Support New Process Development", 3rd International Chemometrics Research Meeting, Veldhoven, The Netherlands, May 2002. *C.E. Miller, J.C. Steichen, B.A. Kirsch, D. A. Russell, "Utilizing Information Technology Developments for Process Spectroscopy", FACSS Conference, Detroit MI, October 2001. *C.E. Miller, J.W. Hawkins, C.M. Johnson, L.K. Bailey, E. Stridde, "On-Line Solids Composition Monitoring by NIR: The Journey from Theory to Practice", International Diffuse Reflectance Conference, Chambersburg PA, August 2000. C.E. Miller, "Chemometrics for On-Line Spectroscopy Applications- Theory and Practice", 6th Scandanavian Symposium on Chemometrics (SSC6), Porsgrunn, Norway, August 15-19, 1999. *C.E. Miller, "Chemometrics and NIR: A Match Made in Heaven?", Eastern Analytical Symposium, Somerset NJ, Nov. 15-20, 1998. *C.E. Miller, "Multivariate Curve Resolution and Process Spectroscopy- A Powerful Combination", American Chemical Society Spring National Meeting, Dallas TX, March 29-April 2, 1998. *C.E. Miller, "Chemometric Models 'On The Line'", Eastern Analytical Symposium, Somerset NJ, Nov. 16-21, 1997. *C.E. Miller, "Delivering Analytical Technology to Where the Money Is- What's Needed in the Toolbox?", Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Conference, Providence RI, Oct. 26-30, 1997. *C.E. Miller, "Diagnostics and Quality Control of Multivariate Calibrations- Theory and Practice", Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Conference, Providence RI, Oct. 26-30, 1997. H.S. Gold, A.M. Brearley, C.E. Miller, A.J. Owens, M.J. Piovoso, D.A. Russell, "Closing the Loop: Near-Infrared Spectroscopy for Process Control in the Chemical Industry", 8th International Conference on Near-Infrared Spectroscopy, Essen, Germany, Sept. 15-19, 1997. *C.E. Miller, "Mass-Production and Maintenance of Multivariate Calibrations for Process Spectrometers", Eastern Analytical Symposium, Somerset, NJ, Nov. 17-22, 1996. *C.E. Miller, "The Use of Chemometric Techniques in Process Analytical Method Development and Operation", NIR '95, The 7th International Conference on Near-Infrared Spectroscopy, Montreal, Canada, Aug. 6-11, 1995. C.E. Miller, "The Use of Chemometric Techniques in Process Analytical Method Development and Operation", INCINC '94, The First International Chemometrics Inter-Net Conference, Sept. 26-Nov. 14, 1994. C.E. Miller, "Attempts to Improve the Understanding of Near-Infrared Methods Through 2-Block Modeling", Poster, Eastern Analytical Symposium, Somerset, NJ, Nov. 12-19, 1993. C.E. Miller, "Heat Seal Strength Assessment by Near-Infrared Spectroscopy, Eastern Analytical Symposium, Somerset, NJ, Nov. 14-17, 1994. *C.E. Miller, "Some Fringe Benefits of Factor-Based Calibration Techniques", Eastern Analytical Symposium, Somerset, NJ, Nov. 12-19, 1993. *C.E. Miller, "Rapid and Non-Destructive Quality Assessment of Polymeric Films Using Near-Infrared Spectroscopy", SPE Polyolefins VIII International Conference, Feb. 21-24, 1993, Houston TX. C.E. Miller, "PLS-2 Block Modeling Between NIR and NIR-Raman Spectroscopy", Poster, 5th Intl. Conf. on Near-infrared Spectroscopy, Haugesund, Norway, June 1992, received poster award. *C.E. Miller, "NIR-More than a Non-invasive Composition Sensor: Applications to Polymeric Food Packaging", 5th Intl. Conf. on Near-infrared Spectroscopy, Haugesund, Norway, June 1992. *C.E. Miller, "Rapid Determination of Quality Parameters of Food Packaging Laminates by Near-IR Spectroscopy", 1992 Pittsburgh Conference and Exposition, New Orleans, LA, March 9-13, 1992. T. Isaksson, C.E. Miller, T. Næs, "Non-destructive Near-IR and NIT Determination of Fat, Water and Protein in Plastic-wrapped, Homogenized Meat", 1992 Pittsburgh Conference and Exposition, New Orleans, LA, March 9-13, 1992. C.E. Miller, N.M. Reynolds, poster: "The Use of Principal Components Analysis for Detailed Observation of the Effects of Deformation and Relaxation on the C=O Stretching Band of a Block Polyurethane", 8th Intl. Conf. on Fourier Transform Spectroscopy, Luebeck-Travemuende, Germany, Sept. 1991. *C.E. Miller, "Non-destructive NIR Analyses of Bulk Polymeric Systems", 4th Intl. Conf. in Near-Infrared Spectroscopy, Aberdeen, Scotland, Aug. 1991. W. Sigmund, C.E. Miller, W.H. Meyer, G. Wegner, poster: "Wechselwirkung zwischen Pulveroberflaechen und polymeren in der keramischen Verfahrenstechnik" ("Interactions between Powder Surfaces and Polymers in Ceramic Processing"), Bayreuth Polymer and Material Research Symposium, 8-10 April 1991, Bayreuth, Germany), received poster award. *C.E. Miller, "NIR Diffuse Reflectance Analysis of Synthetic Polymers" 5th International Diffuse Reflectance Conference, Chambersburg PA, August 12 17, 1990. *C.E. Miller, "NIR Spectroscopy of Synthetic Polymers", Award Address (Tomas Hirschfeld Award in Near infrared Analysis), 1990 Pittsburgh Conference and Exposition, New York, NY, March 5 9, 1990. C.E. Miller, T K. Yin, "NIR Reflectance Analysis of Poly[octadecyl methacrylate] Adsorbed on Alumina", 63rd Colloid and Surface Science Symposium, Seattle WA, June 18 21, 1989. C.E. Miller, "Analysis of Synthetic Polymers by Near infrared Spectroscopy and Multivariate Calibration Methods", 72nd Canadian Chemical Conference and Exhibition, Victoria BC, Canada, June 4 8 1989. D.E. Honigs, C.E. Miller, "Regular and Anomalous Particle Size Effects in Near IR Spectroscopy", Eastern Analytical Symposium, New York NY, September 1987. C.E. Miller, D.E. Honigs, "Baseline and Scatter Correction Using a Quantum Mechanical Filter", Eastern Analytical Symposium, New York NY, September 1987. D.E. Honigs, B.R. Buchanan, C.E. Miller, E. Ciurczak, "Near
infrared Analysis", Fifth International Symposium on New Spectroscopic
Methods for Biomedical Research, Seattle, WA, October 7 11, 1986.
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Eigenvector Research, Inc., 830 Wapato Lake Road, Manson, WA 98831 |